Polymer-coated pH-responsive high-density lipoproteins
نویسندگان
چکیده
منابع مشابه
FeMn2O4 nanoparticles coated dual responsive temperature and pH-responsive polymer as a magnetic nano-carrier for controlled delivery of letrozole anti-cancer
Objective(s): For cancer cells, an efficient and selective drug delivery vehicle can remarkably improve therapeutic approaches. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 NPs and their incorporation in a dual temperature and pH-responsive polymer, which can serve as an efficient drug carrier. Materials and Methods: MnFe2O4 NPs were synthesized by chemical co-pr...
متن کاملHighly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
Dopamine is a neurotransmitter commonly used in clinical treatment. Polydopamine (PDA) has excellent histocompatibility and biosafety and can efficiently convert near-infrared reflection (NIR) to thermal energy. In this study, PDA was used as a promising carrier, and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@ poly(allylamine)-citraconic anhydride [Dox@PAH-cit]...
متن کامل[High-density lipoproteins].
the accurate mechanism of how EIIC transports a sugar has not been clearly demonstrated yet. To investigate more detailed and accurate transportation mechanisms, we performed collective variable-based steered molecular dynamics (CVSMD) simulations. Our simulation shows the spontaneous transportation of the sugar toward the opposite side of the membrane with the preserved H-bonding interactions,...
متن کاملpH-responsive high-density lipoprotein-like nanoparticles to release paclitaxel at acidic pH in cancer chemotherapy
BACKGROUND Nanoparticles undergoing physicochemical changes to release enclosed drugs at acidic pH conditions are promising vehicles for antitumor drug delivery. Among the various drug carriers, high-density lipoprotein (HDL)-like nanoparticles have been shown to be beneficial for cancer chemotherapy, but have not yet been designed to be pH-responsive. METHODS AND RESULTS In this study, we de...
متن کاملMaturation of high-density lipoproteins.
Human high-density lipoproteins (HDLs) are involved in the transport of cholesterol. The mechanism by which HDL assembles and functions is not well understood owing to a lack of structural information on circulating spherical HDL. Here, we report a series of molecular dynamics simulations that describe the maturation of discoidal HDL into spherical HDL upon incorporation of cholesterol ester as...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2016
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2016.03.005